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A single ivermectin (customary) dose clears the pores and skin-dwelling microfilarial progeny of grownup worms (macrofilariae) and quickly impedes the release of such progeny by feminine macrofilariae, but a macrofilaricidal effect has been deemed minimal.
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Ninety-six of the one hundred seventy five instances from Cameroon (fifty five%) have been encephalopathic in nature; 61 had ample clinical and laboratory knowledge to support a analysis of 'Possible' or 'Attainable' L. loa Encephalopathy temporally Related to treatment with Mectizan® (PLERM) (see Further File 6 for case definitions).
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